Buy AKB48 Online, AKB48 is a pentyl indazole with structural similarity to JWH 018 adamantyl carboxamide which are synthetic cannabinoids (CBs) that may be sold for recreational use. AKB48 N-(5-fluoropentyl) analog differs structurally from AKB48 by having fluorine at the terminal carbon of the pentyl chain.
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Buy AKB48 Online, AKB48 is a pentyl indazole with structural similarity to JWH 018 adamantyl carboxamide which are synthetic cannabinoids (CBs) that may be sold for recreational use. AKB48 N-(5-fluoropentyl) analog differs structurally from AKB48 by having fluorine at the terminal carbon of the pentyl chain. While the physiological properties of this compound are not known, quinolones with adamantyl-carboxamide moieties display high affinity for the peripheral CB2 receptor but greatly reduced affinity for the central CB1 receptor.1 This product is intended for research and forensic applications.
Buy AKB48 Online, 5F-APINACA (5F-AKB-48) is an analogue of APINACA (AKB-48) fluorinated on the terminal
carbon of the pentyl side chain. It belongs to the category of synthetic cannabinoid receptor
agonists (SCRAs), which have affinity for CB1 and CB2 receptors with activation of the former
accounting for the psychoactive effects of these substances. 5F-APINACA is a psychoactive
substance and has effects similar to Δ9-THC, which, in accordance with the Convention on
Psychotropic Substances of 1971, is listed as Schedule I substance.
5F-APINACA binds with nanomolar affinity to CB1 and CB2 receptors (Ki -value of 1.94 and 0.27
nM, respectively), i.e. with a two-fold and 265-fold higher affinity as compared to THC.
Buy AKB48 Online, 5FAPINACA stimulates CB1-induced [35S]GTPγS binding with high potency and efficacy, and at 0.1
mg/kg i.v. it increases dopamine transmission in the nucleus accumbens. 5F-APINACA is mainly metabolized by hydroxylation and loss of the fluorine from the N-pentyl side chain.
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Detailed information on the toxic effects of 5F-APINACA is not available. In general, SCRAs
may produce nausea, vomiting, agitation, hallucinations, panic attacks, tachycardia, hypertension,
and occasionally chest pain, acute psychosis, and seizures. Clinical signs of toxicity (chest pain,
tachycardia, hypertension, and agitation) following smoking of 5F-APINACA usually resolve
within 4 to 10 h and may require treatment with benzodiazepines. 5F-APINACA smoking has
been associated with myocardial infarction.
Buy AKB48 Online, One non-fatal case was reported in a young man
following smoking of 5F-APINACA 4 h before the onset of chest pain. Five similar cases were
reported after use of other adamantyl-substituted SCRAs.
Long term use of 5F-APINACA is characterized by loss of appetite, cognitive impairment,
breathlessness, cardiac conditions requiring medication, skin ablations, tooth decay, lethargy,
apathy, tremors and insomnia, which are all exacerbated when attempting to reduce use.
Buy AKB48 Online, Studies on abuse and dependence potential of 5F-APINACA have not been performed, but users